Podcasts

Autoimmune Roadblocks to IVF: How ANA Affects Fertility

May 12, 2025

Autoimmune Roadblocks to IVF: How ANA Affects Fertility

We're diving into what a positive ANA and autoimmunity could mean for your chances of pregnancy success.

Autoimmune markers like antinuclear antibodies (ANA) are often overlooked, but they could be silently interfering with your IVF success.

In this episode, we dive deep into how positive ANA affects implantation, increases pregnancy loss, and contributes to failed IVF cycles. We explore what the research says, why these markers matter even if you don't have a formal autoimmune diagnosis, and how our Fab Fertile Method can help.

Whether you're preparing for IVF or struggling with unexplained infertility or miscarriage, this episode offers insight, hope, and a path forward.

This episode is for you:

 You have positive ANA or other autoimmune markers and want to understand how they impact IVF success.

 You’ve experienced failed implantation, recurrent miscarriage, or unexplained IVF failure and suspect autoimmunity could be a factor.

 You’re looking for functional medicine/nutrition strategies to reduce inflammation, balance your immune system, and improve your chances of a successful pregnancy.

In this episode you'll learn:

How ANA and other autoantibodies disrupt embryo implantation and hormone balance

The latest research linking ANA to lower IVF pregnancy rates

How chronic inflammation and gut health influence immune function

Functional strategies to rebalance the immune system: anti-inflammatory nutrition, gut repair, targeted supplements like NAC and LDN, detox support, and stress management

How to integrate medical and holistic approaches for better outcomes

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RESOURCES

📩 Get your free 10-day elimination diet plan! Email hello@fabfertile.ca with the subject line 10 DAY to receive your guide and take the first step toward reconnecting with your fertility.

How To Prevent and Reverse Autoimmune Disease and Get Pregnant https://fabfertile.com/blogs/podcasts/how-to-prevent-and-reverse-autoimmune-disease-and-get-pregnant?_pos=3&_sid=ef2bd19b9&_ss=

Why Your Gut Microbiome Matters for Low AMH and High FSH:  https://fabfertile.com/blogs/podcasts/why-your-gut-microbiome-matters-for-low-amh-and-high-fsh?_pos=5&_sid=cb98d643f&_ss=r

Detox Your Way to Better Egg Health: Strategies to Improve Fertility Naturally:  https://fabfertile.com/blogs/podcasts/detox-your-way-to-better-egg-health-strategies-to-improve-fertility-naturally?_pos=3&_sid=edba88831&_ss=r

Why A Mineral Deficiency Matters When You Are Trying To Conceive:  https://fabfertile.com/blogs/podcasts/why-a-mineral-deficiency-matters-when-you-are-trying-to-conceive-with-terra-vitiello?_pos=1&_sid=ebabb1fca&_ss=r

From Infertility to Adverse Obstetrical Outcomes – A Meta-Analysis:  This comprehensive analysis highlights that ANA-positive women undergoing IVF/ICSI have a 50% lower pregnancy rate compared to ANA-negative counterparts, alongside higher miscarriage and lower implantation rates. 🔗 Read the study - https://pubmed.ncbi.nlm.nih.gov/36621091/

Antinuclear Antibodies Predict a Poor IVF-ET Outcome:  Findings suggest that the presence of ANAs significantly interferes with oocyte and embryo development, reducing implantation and pregnancy rates. 🔗 Read the study - https://pubmed.ncbi.nlm.nih.gov/22429204/

Review on Autoimmune Reactions in Female Infertility: Antibodies to Zona Pellucida:  This review discusses how antibodies targeting the zona pellucida can impair fertilization, contributing to infertility. 🔗 Read the review - https://pmc.ncbi.nlm.nih.gov/articles/PMC3189473/

The Effect of Prednisolone Treatment on Pregnancy Rates in IVF Patients with Thyroid Autoimmunity:  The study examines how prednisolone administration may improve pregnancy rates in women with thyroid autoimmunity undergoing IVF. 🔗 Read the study - https://pubmed.ncbi.nlm.nih.gov/34712086/

Our favorite fertility tracker (use code FABFERTILE15 to save 15) - https://www.inito.com/en-us/?srsltid=AfmBOoo85sXu_esmFN5Kz6iysaTkBKgYl35Jubv-BaLkkxXVggdk6nes

Fab Fertile Method https://www.fabfertile.com/what-we-do/

Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii

Not sure where to start? Book a 15-minute call here and we’ll give you options to help.

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💛 Join my free Facebook group: Get Pregnant Naturally With Low AMH and/or High FSHhttps://www.facebook.com/groups/451444518397946

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Please note we only promote products that Sarah Clark or her Fab Fertile team has tried and believes are beneficial for someone who is TTC. We may receive a small commission.